For Clients At The End Of Their One-On-One Work

The medicine isn't the work. It's the catalyst.

The work is what we've already done with you — the stabilization, the family alignment, the nervous-system regulation, the readiness to actually meet what surfaces.

Plant medicine integration is the final phase of an Epic Journey engagement — offered only after a client has been prepared, screened, and aligned. We do not administer substances. We prepare you, walk you into the ceremony with our vetted, legally licensed partner facilitators in Oregon, Colorado, Mexico, Costa Rica, Peru, the Netherlands, and Jamaica, and then we spend at least 90 days integrating what you encounter into how you actually live.

Preparation is everything. · Set & setting are not optional. · Integration is where transformation lives.

Phase 6 of The Epic Method™

Plant medicine integration is the capstone of our proprietary 6-phase recovery protocol. See the full method — bond, clinical foundation, physical restoration, identity reconstruction, integration, and plant medicine.

See The Epic Method →
Why It's Last

A catalyst only works on prepared ground.

The reason most plant medicine experiences don't translate into lasting change isn't the medicine — it's that the person who arrived to the ceremony wasn't ready to actually meet it. They came still dysregulated, still in active addiction, still avoiding the family dynamic that's been driving everything, still expecting the medicine to do the work for them.

By the time we walk a client into a ceremony with one of our partner facilitators, they've usually spent 90–180 days with us doing the foundational work: sobriety stabilization, somatic and nervous-system practice, daily journaling (often with The Epic Journal), the hard family conversations, the resentments and fears they've been outrunning. That groundwork is what makes the medicine safe, and what makes what it surfaces actually integratable on the other side.

The Three Phases

How we actually do this.

Three phases. None of them optional. The middle one is the only one that includes the medicine itself.

Phase 01
4–12 Weeks

Preparation & Alignment

Clinical screening for fit. Honest review of personal and family psychiatric history, current medications, cardiac health, and current life stability.

  • Comprehensive intake & medical contraindication review
  • SSRI/MAOI taper coordination (with prescriber)
  • Nervous-system regulation & breathwork practice
  • Intention-setting (specific, not abstract)
  • Diet & lifestyle prep (Dieta where applicable)
  • Family alignment so you're not walking into the experience carrying unprocessed dynamics
Phase 02
2–10 Days

Ceremony with Licensed Partners

The medicine experience itself happens with our vetted partner facility, chosen specifically to fit your needs, medical profile, and the medicine best suited to what you're working through.

  • Personally matched to the right facility & facilitator
  • Travel logistics handled end-to-end
  • Pre-ceremony grounding call with Preston
  • Direct point-of-contact during the experience
  • Medical oversight built into every partner site
  • Same-day post-ceremony debrief call
Phase 03
90–180+ Days

Integration & Translation

This is where peak experiences become permanent change. Without it, the insights fade within weeks. With it, they restructure how you actually live.

  • Weekly 1:1 integration sessions with Preston
  • Somatic processing of what surfaced
  • Daily practice protocol (journal, breath, movement)
  • Relational repair work with family / partner
  • Concrete behavioral commitments & accountability
  • Long-term mentorship continuation when wanted
The Medicines

What we work with — and what the research shows.

The medicine matched to you depends on what you're working through, your medical profile, your prior experience, and what kind of structure you need. We don't recommend a medicine until we've done the clinical screening.

Most Studied · FDA Breakthrough Therapy

Psilocybin

From Psilocybe cubensis · synthesized or fungal

Most common entry point into this work. FDA Breakthrough Therapy designation in 2018 (treatment-resistant depression) and 2019 (major depressive disorder). Sessions of 4–6 hours in a clinical container.

Research: Johns Hopkins, NYU, and Imperial College London studies show large and durable reductions in depression and end-of-life anxiety after 1–2 supervised sessions paired with psychotherapy. Significant signals in alcohol use disorder, tobacco use disorder, and OCD.

Partners: Oregon licensed service centers (Measure 109), Colorado healing centers (Prop 122), Netherlands (legal psilocybin truffles), Jamaica

Ceremonial · Traditional Indigenous Use

Ayahuasca

Banisteriopsis caapi + Psychotria viridis · DMT + MAOI brew

A 4–6 hour ceremonial brew used for centuries by Amazonian traditions. The combination of DMT with an MAOI produces a longer, deeply somatic and emotional experience often described as confronting and clarifying rather than recreational.

Research: Brazilian and Spanish studies show rapid antidepressant effects with elevated post-session BDNF (a marker of neuroplasticity). Observational research on long-term ceremonial users shows lower rates of substance use and improved emotional regulation.

Partners: Established retreat centers in Costa Rica, Peru (Sacred Valley & Iquitos), and Mexico, all with medical oversight and integration support

Highest Care · For Opioid Use Disorder

Ibogaine

From Tabernanthe iboga · Used in licensed medical clinics only

Specifically used in our practice for clients with established opioid use disorder who have not responded to conventional treatment. Requires 24–36 hour medical supervision and full cardiac clearance. This is not used recreationally and not appropriate for most other presentations.

Research: Observational studies in Mexico and New Zealand show significant reduction in opioid withdrawal severity and post-treatment opioid craving. Cardiac risk is real and requires ECG screening, electrolyte balancing, and on-site medical oversight throughout.

Partners: Licensed Mexican medical clinics with on-site MD oversight, ECG monitoring, and dedicated cardiac protocols

Brief · Powerful · Specialized

5-MeO-DMT (Bufo)

From Incilius alvarius (synthesized form preferred)

An exceptionally brief (15–30 minute) but profound non-dual experience. Used carefully and only after a client has completed prior psilocybin or ayahuasca work and demonstrated integration capacity. Not a starting point.

Research: Early observational research suggests rapid reductions in depression and anxiety, with effects persisting at 4-week follow-up. Strong recommendation in the literature for prior preparation and rigorous integration.

Partners: Specialized retreats in Mexico with experienced facilitators, medical screening, and prior verification of client readiness

The Neuroscience

What's actually happening in the brain.

Based on peer-reviewed research from Imperial College London (Carhart-Harris), Johns Hopkins (Griffiths, Davis), NYU (Ross), Compass Pathways trials, and the Multidisciplinary Association for Psychedelic Studies. This is the clinical model — not a metaphor.

5-HT2A

Serotonin Receptor Agonism

Psilocybin and DMT bind to the 5-HT2A receptor in cortical pyramidal neurons. This is the molecular trigger for everything that follows.

DMN↓

Default Mode Network Modulation

The brain network responsible for the constant self-referential narrative quiets dramatically. Researchers correlate this with "ego dissolution" and freed-up cognitive flexibility.

BDNF↑

Neuroplasticity Window

Increased BDNF and synaptic growth open a window of unusual neural plasticity. The brain becomes temporarily capable of forming new patterns it had been locked out of.

CRIT

Critical Period Re-Opening

Recent research (Dolen 2023) suggests psychedelics may temporarily re-open critical learning periods, allowing rewiring of patterns established earlier in life.

The window opens for roughly 2–4 weeks after a session. That window is exactly when integration matters most — new patterns either get installed and reinforced, or the system reverts.

Peer-Reviewed Research Sources

Clinical Screening

Who this is for — and who it isn't.

This is where we are most direct with clients. The vast majority of harm in plant medicine work comes from people who shouldn't have done it doing it anyway. We screen every client clinically before any referral is made. We turn people away when it's not the right fit.

A Fit If

Plant medicine work can be considered if you are:

  • An adult (25+) with treatment-resistant depression, PTSD, or chronic anxiety that hasn't responded to conventional approaches
  • In established sobriety (minimum 90 days) for substance use disorder, with appropriate aftercare in place
  • Working through existential distress, grief, or end-of-life process
  • Carrying complex trauma with a regulated nervous system and a therapist or coach already in place
  • Cardiovascularly healthy with no untreated cardiac conditions
  • Off SSRIs / MAOIs / lithium under your prescriber's supervision (timing varies by medicine)
  • Genuinely committed to 90+ days of integration afterward — not just the peak
Not A Fit If

Plant medicine work is contraindicated if you have:

  • Personal or first-degree-relative history of schizophrenia, bipolar I, or psychotic disorders
  • Active suicidality or recent suicide attempt
  • Severe or untreated cardiac conditions (especially for ibogaine and ayahuasca)
  • Pregnancy or breastfeeding
  • Active substance use without prior stabilization
  • Current use of SSRIs, MAOIs, or lithium without medically supervised taper
  • Unrealistic expectations — expecting the medicine to "fix" you without doing the work before and after
  • Major unprocessed acute trauma without prior stabilization with a trauma-informed clinician
Why we're this strict: Adverse events in plant medicine work almost always trace back to inadequate screening. A client with latent bipolar I can be precipitated into a months-long manic episode. A client with undiagnosed cardiac arrhythmia can have a cardiac event under ibogaine. A client in active psychosis can be deepened into it. None of these outcomes are necessary if the screening is done honestly. We do the screening honestly and we have turned clients away. That is a feature, not a flaw.
Partner Network

Where the ceremony actually happens.

Epic Journey does not administer plant medicine in California. Every ceremony happens with one of our vetted partner facilities in jurisdictions where the work is legally licensed or operates under established national frameworks. We do not refer to underground or unlicensed providers.

Psilocybin Service Centers

Oregon, USA · Measure 109

State-licensed clinical psilocybin service centers operating under Oregon's regulated framework. Trained facilitators, medical screening, in-person preparation and same-day integration.

Healing Centers

Colorado, USA · Proposition 122

Colorado licensed natural medicine healing centers under the state's Natural Medicine Health Act. Psilocybin work with credentialed facilitators.

Ayahuasca Retreats

Costa Rica · Peru · Mexico

Established ceremonial retreat centers with experienced curanderos, medical staff on-site, structured pre- and post-ceremony work, and proven integration support infrastructure.

Ibogaine Medical Clinics

Mexico

Licensed Mexican medical clinics with on-site MDs, full cardiac screening (ECG, electrolytes), 24–36 hour medical monitoring, and dedicated protocols for opioid use disorder.

Truffle Retreats

Netherlands

Legal psilocybin truffle retreats in the Netherlands, where the truffle form remains legal. Professionally facilitated with proper preparation and same-week integration.

Psilocybin Retreats

Jamaica

Psilocybin retreats in Jamaica where the medicine is decriminalized. Used selectively where the right facility, facilitator, and structure are confirmed in advance.

Every partner is vetted on five criteria: legal standing in their jurisdiction, medical oversight on-site, facilitator credentials and training hours, integration infrastructure, and a track record we've personally verified. When a facility doesn't meet all five, we don't refer to it.

Integration

Where the medicine becomes life.

The 90 days after the ceremony are more important than the ceremony.

Without integration, plant medicine experiences fade into vivid memories that don't change anything. The insights stop showing up. The somatic releases get re-armored. The relational openings close back down. Researchers consistently find that integration support is the single strongest predictor of whether a session translates into durable change.

We don't walk you to the door of the ceremony and walk away. We walk you back through it for the next three to six months, and we translate what you encountered into how you actually live.

Every week for the first 90 days, we work one-on-one with you on what surfaced — somatic processing of the material that came up, daily practice protocols, the relational repair work the medicine made possible, the behavioral commitments that turn insight into change. After day 90, most clients stay engaged in recovery coaching and mentorship for as long as serves them.

Integration is the work Epic Journey was built for. The medicine just makes the work possible. The 90 days afterward are where you and I actually do it.

Plant Medicine FAQ

The questions families actually ask.

Honest answers. If your question isn't here, the consult is free.

Does Epic Journey administer plant medicine?

No. Epic Journey provides preparation and integration coaching. The plant medicine experience itself is always conducted by our vetted partner facilitators in jurisdictions where the work is legally licensed.

We do not administer, distribute, or transport controlled substances. We never refer to underground or unlicensed providers.

Why does plant medicine work come at the END of an engagement?

Because the medicine is not the work — it's the catalyst.

Without prior stabilization (sobriety, nervous-system regulation, family alignment, clarity on what you're actually working through), most people don't get what they came for, and a small percentage are harmed.

The 90–180 days of foundation work we do beforehand is what makes the experience safe, integratable, and actually transformational.

Who is NOT a fit for plant medicine work?

Anyone with personal or first-degree-relative history of schizophrenia, bipolar I, or psychotic disorders. Active suicidality. Severe untreated cardiac conditions (especially ibogaine and ayahuasca). Pregnancy or breastfeeding.

Current SSRI / MAOI / lithium use without medically supervised taper. Anyone in active addiction without prior stabilization. Anyone expecting the medicine to "fix them" without doing the work before and after.

We screen all of this clinically. We have turned clients away and we will continue to.

What does the research actually show?

Psilocybin received FDA Breakthrough Therapy designation in 2018 (treatment-resistant depression) and 2019 (major depressive disorder). Johns Hopkins, Imperial College London, and NYU studies show large, durable reductions in depression scores after 1–2 supervised sessions paired with psychotherapy.

Ibogaine observational studies in Mexico and New Zealand show significant reductions in opioid withdrawal severity and post-treatment opioid craving.

Ayahuasca research from Brazil and Spain shows rapid antidepressant effects and elevated BDNF (a marker of neuroplasticity).

These are early-but-strong signals, not cures. We talk about them honestly.

How much does it cost?

Cash-pay only. We do not bill insurance for this work.

Pricing depends on (1) the Epic Journey preparation + integration package and (2) the partner facility you're matched with.

Oregon psilocybin service centers typically run $3,000–$6,000 per session. International ayahuasca and ibogaine retreats range from $5,000 to $20,000+ depending on duration, medical oversight, and accommodations.

Exact quotes on the consult.

Is this legal?

Where Epic Journey works with you (preparation + integration in California) — yes, fully legal.

The ceremony itself only happens in jurisdictions where it is legally licensed or operates under established national frameworks: Oregon (Measure 109), Colorado (Prop 122), or international clinics in Mexico, Costa Rica, Peru, the Netherlands, and Jamaica.

We do not refer anyone to underground work in California or in any U.S. state where the work is not legally authorized.

What if I've never done psychedelics before?

Most of our plant medicine clients have not. First-time experience in a clinically supervised, legally licensed setting with proper preparation is dramatically safer and more effective than the alternatives.

We never recommend self-administered or underground work as a starting point. The preparation, the container, and the integration are what make the experience worth doing.

What does integration actually involve?

Integration is the work of taking what came up during the medicine experience — insights, somatic releases, relational shifts, repressed material — and translating it into actual changes in how you live.

Weekly sessions for a minimum of 90 days post-ceremony. Somatic processing. Daily practice protocols. Family or relational repair. Concrete behavioral commitments.

Research consistently shows integration support is the strongest predictor of durable outcomes. Without it, peak experiences fade and the changes don't stick.

Can plant medicine help with addiction?

There is meaningful preliminary research — particularly ibogaine for opioid use disorder (significant reduction in withdrawal severity and post-treatment craving) and psilocybin for alcohol and tobacco use disorder.

This work is most effective AFTER initial stabilization — typically 90 days of sobriety, stable nervous system, and supportive structure already in place.

It is not a replacement for foundational recovery work. It is something that can come after the foundational work is built.

What are the risks?

Real risks exist. For people with the contraindications above, plant medicine can precipitate psychotic episodes, dangerous cardiac events, or worsen the very conditions they came to heal.

Even for properly screened candidates, integration challenges are common in the weeks after — surfaced trauma, mood instability, sleep disruption — which is precisely why integration support is non-negotiable.

We are direct with clients about all of this on the consult. We don't sell the medicine. We tell you what's true.

What medicines do you NOT work with?

We do not refer to facilities offering DMT extractions, MDMA-assisted therapy outside of approved research settings, LSD, ketamine outside a U.S. clinical practice, or any underground or unlicensed work in California or other U.S. states.

If you've been considering one of those routes, we'll have an honest conversation about it before recommending the legal, structured alternative.

How do we start?

Book a free 15-minute consult. We'll talk through your situation, your history, what you're working with, and whether this work is even appropriate right now.

If it's a fit, we begin with the preparation phase. If it's not yet, we tell you what would need to be in place first — and we often work with people on that foundation for months before this is even on the table.

This is not for everyone.
If it's for you, we'll know on the consult.

One conversation. Honest screening. We'll tell you whether the timing is right, whether the foundation is in place, and what would need to happen first if it's not.